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  Indian J Med Microbiol
 

Figure 1: Hematoxylin–eosin (H and E) and trichrome stained of ACE2 KO mice kidney tissue after the treatment of AAI. (a) The wild-type (WT) mice treated with PBS steady gained weight; however, ACE KO mice after the four-week treatment of AAI lost weight. All values are expressed as the mean ± SD from each group. * and ** indicate P < 0.05 and P < 0.01, respectively, compared with the mice body weight at first day. (b) H and E stained of kidney tissue sections were form ACE KO mice treated with AAI for two and four weeks and sacrificed after another two weeks. Compared with the AAI-untreated group, the AAI group showed severe red blood cells infiltration in AAI groups. The trichrome stained kidney tissue sections were from ACE2 KO mice treated with AAI for two and four weeks and sacrificed after another two weeks. Compared with the AAI-untreated group, the AAI group showed intrarenal fibrosis (red color arrowheads) and severe interstitial tissue damage (blue color tissue)

Figure 1: Hematoxylin–eosin (H and E) and trichrome stained of ACE2 KO mice kidney tissue after the treatment of AAI. (a) The wild-type (WT) mice treated with PBS steady gained weight; however, ACE KO mice after the four-week treatment of AAI lost weight. All values are expressed as the mean ± SD from each group. * and ** indicate <i>P</i> < 0.05 and <i>P</i> < 0.01, respectively, compared with the mice body weight at first day. (b) H and E stained of kidney tissue sections were form ACE KO mice treated with AAI for two and four weeks and sacrificed after another two weeks. Compared with the AAI-untreated group, the AAI group showed severe red blood cells infiltration in AAI groups. The trichrome stained kidney tissue sections were from ACE2 KO mice treated with AAI for two and four weeks and sacrificed after another two weeks. Compared with the AAI-untreated group, the AAI group showed intrarenal fibrosis (red color arrowheads) and severe interstitial tissue damage (blue color tissue)