International Journal of Preventive Medicine

REVIEW ARTICLE
Year
: 2022  |  Volume : 13  |  Issue : 1  |  Page : 142-

An updated systematic review and meta-analysis on association of serum lipid profile with risk of breast cancer incidence


Atefeh Amerizadeh1, Golnaz Vaseghi2, Ziba Farajzadegan3, Sedigheh Asgary1 
1 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2 Applied Physiology Research center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Community Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Sedigheh Asgary
Department of Cardiovascular Research, Isfahan University of Medical Sciences, PO Box: 81465-1148, Isfahan
Iran

Background: This meta-analysis was performed to investigate the effect of serum lipids on the risk of breast cancer incidence. Methods: PubMed, Web of Science, Scopus, and EMBASE were searched systematically from January 1998 to April 2019. Inclusion criteria were English observational studies (cohort or case-control) and the concentration of at least one of the lipid profile components (total cholesterol/triglycerides/low-density lipoprotein cholesterol/high-density lipoprotein cholesterol) measured before a diagnosis of breast cancer (BC). The studies were included in which the relative risk (RR) had been reported with 95% confidence intervals (CIs). A random-effects model was used. Results: A total of 25 studies were found, including 2,882,789 participants in cohort studies with 45,481 cases with BC, and 1983 BC cases and 2963 case-control studies. Combined RR of cohort studies for the highest versus lowest for the BC was LDL-C: 0.95 (95% CI: 0.89–1.01), triglycerides (TG): 0.95 (95% CI: 0.91–0.99; P = 0.02), total cholesterol (TC): 0.98 (95% CI: 0.91–1.05), and HDL-C: 0.86 (95% CI: 0.63–1.18). Combined RR of case-control studies for the highest versus lowest was LDL-C: 1.08 (95% CI: 0.78–1.48), TG: 1.73 (95% CI: 0.94–3.18), TC: 1.02 (95% CI: 0.80–1.29), and HDL-C: 0.79 (95% CI: 0.65–0.97). Conclusions: Based on the results, it can be concluded that only TG but not TC and/or LDL-C had a significant inverse association with the risk of BC incidence. HDL-C showed a significant protective effect against breast cancer in postmenopausal women and case-control studies.


How to cite this article:
Amerizadeh A, Vaseghi G, Farajzadegan Z, Asgary S. An updated systematic review and meta-analysis on association of serum lipid profile with risk of breast cancer incidence.Int J Prev Med 2022;13:142-142


How to cite this URL:
Amerizadeh A, Vaseghi G, Farajzadegan Z, Asgary S. An updated systematic review and meta-analysis on association of serum lipid profile with risk of breast cancer incidence. Int J Prev Med [serial online] 2022 [cited 2022 Dec 9 ];13:142-142
Available from: https://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2022;volume=13;issue=1;spage=142;epage=142;aulast=Amerizadeh;type=0