Background: We aimed to assess effects of circuit resistance training (CRT) on glycemic control of females with Type II diabetes. Methods: Twenty obese and overweight females with diabetes Type II were randomly selected in two groups (circuit resistance exercise and control). CRT performed in 3 days/week for 3 months, and the serum and body parameters were assessed. Data were analyzed by Mann-Whitney U-test and Wilcoxon Signed-Rank test in SPSS version 19. Results: Mean age in the CRT and control group was 50.2 ± 4.89 years and 51.3 ± 6.63 years, respectively. Results showed significant changes in glycosylated hemoglobin (HbA _1c ) and subcutaneous fat were noted in the CRT group (P = 0.04, P = 0.002, respectively). Also, findings indicated higher HbA _1c in CRT group after intervention in comparison with controls and results showed a significant difference (P = 0.04). Conclusions: According to the positive effect of CRT, it seems that can be recommended for patients with diabetes Type II.