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 Table of Contents  
Year : 2023  |  Volume : 14  |  Issue : 1  |  Page : 87

Cancerous Patient, COVID-19 Vaccination, Blood Viscosity and Stroke-Like Complication

1 Private Academic Consultant, Bangkok, Thailand
2 Honorary Professor, Department of Community Medicine, Dr DY Patil Vidhyapeeth, Pune, Maharashtra, India

Date of Submission22-May-2021
Date of Decision25-May-2021
Date of Acceptance29-May-2021
Date of Web Publication22-Jun-2023

Correspondence Address:
Beuy Joob
Private Academic Consultan, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.ijpvm_217_21

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How to cite this article:
Joob B, Wiwanitkit V. Cancerous Patient, COVID-19 Vaccination, Blood Viscosity and Stroke-Like Complication. Int J Prev Med 2023;14:87

How to cite this URL:
Joob B, Wiwanitkit V. Cancerous Patient, COVID-19 Vaccination, Blood Viscosity and Stroke-Like Complication. Int J Prev Med [serial online] 2023 [cited 2023 Sep 27];14:87. Available from: https://www.ijpvmjournal.net/text.asp?2023/14/1/87/379412

Dear Editor,

The coronavirus disease 2019 (COVID-19) vaccine is the hope for the management of the COVID-19 outbreak. At present, the COVID-19 vaccine is already in use in several countries. An important concern is the adverse effect of vaccination. There are many possible adverse effects of the COVID-19 vaccine including vascular complication. The possible neurological complication due to the COVID-19 vaccine is an important present consideration.[1] There are many recent reports on neurological incidences including stroke-like complication after vaccination.

In a recent local report from Indochina (https://www.reuters.com/world/asia-pacific/thailand-sticks-with-sinovac-vaccine-after-cases-stroke-like-side-effects-2021-04-21/), a post-COVID-19 vaccination stroke-like incidence occurs. A patient with underlying breast cancer is a member of all six affected cases, there is a patient with underlying breast cancer. It is questionable on the exact pathomechanism of the incidence. Indeed, a possible explanation of post-vaccination vascular complication is the change of blood viscosity. The COVID-19 vaccination can result in a change of blood viscosity due to an increased level of immune elements.[2] An increase in immunoglobulin is confirmed as a possible cause of increased blood viscosity.[3] A cancer patient, including the one with breast malignancy, might have a background high-blood viscosity.[4] Therefore, after vaccination, a hyperviscosity might occur, and it might result in a stroke-like event. For COVID-19 vaccination, it should be used with precaution in a patient with the underlying malignancy.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Lu L, Xiong W, Mu J, Zhang Q, Zhang H, Zou L, et al. The potential neurological effect of the COVID-19 vaccines: A review. Acta Neurol Scand 2021. doi: 10.1111/ane. 13417. Online ahead of print.  Back to cited text no. 1
Saadat S, Tehrani ZR, Logue J, Newman M, Frieman MB, Harris AD, et al. Binding and neutralization antibody titers after a single vaccine dose in health care workers previously infected with SARS-CoV-2. JAMA 2021;325:1467-9.  Back to cited text no. 2
Dalakas MC. High-dose intravenous immunoglobulin and serum viscosity: Risk of precipitating thromboembolic events. Neurology 1994;44:223-6.  Back to cited text no. 3
von Tempelhoff G-F, Schönmann N, Heilmann L, Pollow K, Hommel G. Prognostic role of plasmaviscosity in breast cancer. Clin Hemorheol Microcirc 2002;26:55-61.  Back to cited text no. 4


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