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| LETTER TO EDITOR |
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| Year : 2023 | Volume
: 14
| Issue : 1 | Page : 74 |
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COVID-19, vaccination, multisystem inflammatory syndrome, aneurysm, screening and post vaccination death
Beuy Joob1, Viroj Wiwanitkit2
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. D. Y. Patil University, Pune, Maharashtra, India
| Date of Submission | 12-May-2021 |
| Date of Acceptance | 27-Sep-2021 |
| Date of Web Publication | 16-Jun-2023 |
Correspondence Address:
Beuy Joob
Private Academic Consultant, Bangkok 103300
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijpvm.ijpvm_192_21
How to cite this article:
Joob B, Wiwanitkit V. COVID-19, vaccination, multisystem inflammatory syndrome, aneurysm, screening and post vaccination death. Int J Prev Med 2023;14:74 |
How to cite this URL:
Joob B, Wiwanitkit V. COVID-19, vaccination, multisystem inflammatory syndrome, aneurysm, screening and post vaccination death. Int J Prev Med [serial online] 2023 [cited 2023 Sep 27];14:74. Available from: https://www.ijpvmjournal.net/text.asp?2023/14/1/74/378882 |
Dear Editor,
COVID-19 vaccine is the preventive tool against COVID-19. The safety of the new vaccine is the present issue for research. For any vaccination, postvaccination death requires a good investigation. An interesting emerging problem on postvaccination death due to ruptured aneurysms is an interesting observation. The primary investigation by local public health administrators usually reveals no association (for example, see https://healthserv.net/en9417). Theoretically, COVID-19 might cause aberration in homoeostatic system. The clinical association with an aneurysm is also reported. The multisystem inflammatory syndrome, aneurysm, might induce aneurysm.[1] The pathogenesis of COVID-19-induced aneurysm is via the stimulator of interferon genes (STING) pathway,[2] which is an immune-related mechanism. Regarding COVID-19 vaccination, the stimulation on the immune system might occur. There is a possible chance that there might be an immunopathological process inducing aneurysm or superimpose the existed aneurysm. Therefore, a possible interrelation between COVID-19 vaccination and postvaccination death due to ruptured aneurysm requires in-depth research.
At present, for playing safe, it is recommended that COVID-19 vaccination should be provided to only healthy people without any personal illness or risk history. The special high precaution should be noted for any case with underlying thrombohemostatic, immunological, or vascular disease. A good prevaccination screening and a highly selective recruitment process for the new vaccine recipients should be the best preventive measure.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, et al. Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA 2021;325:1074-87.  |
| 2. | Berthelot JM, Drouet L, Lioté F. Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: Delayed over-activation of the STING pathway? Emerg Microbes Infect 2020;9:1514-22. |
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