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Year : 2022  |  Volume : 13  |  Issue : 1  |  Page : 157

The association of opioid use disorder and COVID-19, a longitudinal study

1 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2 Ophthalmic Epidemiology Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
3 Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
4 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mohammad Hassan Emamian
7 Tir SQ, Shahroud University of Medical Sciences, Shahroud
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.ijpvm_68_22

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Background: Coronavirus disease 2019 (COVID-19) quickly spread to the world, causing a pandemic. While some studies have found no link between opioid use disorder (OUD) and COVID-19, the role of opioid on COVID-19 is challenging. The present study aimed to determine the relationship between OUD and COVID-19. Methods: This was a prospective cohort study. We used data from the third phase of the Shahroud Eye Cohort Study on 4394 participants which started in September 2019 and ended before the COVID-19 epidemic in Shahroud in February 2020. The participants were followed for about 13 months till March 26, 2021. COVID-19 was detected by RT-PCR on swap samples from the oropharynx and nasopharynx. The incidence of COVID-19 compared in OUD and non-OUD participants, and relative risk was calculated in log-binomial regression models. Results: Among the 4394 participants with a mean age of 61.1 years, 120 people had OUD. The incidence of COVID-19 in participants with OUD and non-OUD was 4.17% and 6.22%, respectively (P-value: 0356). The relative risk of OUD for COVID-19 was 0.60 (95% confidence intervals: 0.25–1.44; P value: 0.251). Conclusions: OUD was not associated with COVID-19. The claim that people with OUD are less likely to develop COVID-19 is not supported by these data.

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