|LETTER TO EDITOR
|Year : 2021 | Volume
| Issue : 1 | Page : 70
Renin angiotensin converting enzyme 2 and COVID-19: Prevention and treatment
Marzieh Kafami1, Mehdi Nematbakhsh2
1 Department of Physiology, Sazevar University of Medical Sciences, Sabzevar, Iran
2 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
|Date of Submission||27-Sep-2020|
|Date of Acceptance||04-Feb-2021|
|Date of Web Publication||25-Jun-2021|
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Kafami M, Nematbakhsh M. Renin angiotensin converting enzyme 2 and COVID-19: Prevention and treatment. Int J Prev Med 2021;12:70
The 2019 novel corona virus (SARS-CoV-2) has already taken on pandemic proportions, having infected more than seven million people in 213 countries. The increased prevalence of the disease as well as involvement of the angiotensin-converting enzyme 2 (ACE2) have suggested to consider its role in corona virus infection diseases-2019 (COVID-19).
ACE2 is a type-I membrane-bound glycoprotein that cleavages angiotensin I (Ang I) into Ang 1-9 and Ang II into the Ang1-7. Organs such as the heart, liver, kidney, and especially the lungs play a greater role in COVID-19 mortality while a higher expression of ACE2 was detected in these organs. SARS-CoV-2 utilizes ACE2 as an entry receptor in ACE2-expressing cells, and actually inhibit the physiological activity of ACE2. The ACE inhibitors and AngII type-I receptor blockers (ARBs) are the simple choice to increase ACE2 expression, and the binding of soluble ACE2 with SARS-CoV-2 spike may reduce the viral load, and cellular blocking of ACE2 act as pro-inflammatory. Diseases such as asthma, pneumonia, and influenza are dependent on ACE2 activity, and ACE2 activators may prevent the lung against fibrosis. The expression of ACE2 may promote by some vitamins such as vitamins C, D, and B3. In addition, ARBs, metformin and the drugs containing diminazene aceturate also are suggested to be used as ACE2 activators., Collectively, the relationship between ACE2 and SARS-CoV-2 in the treatment of COVID-19 patients cannot be ignored.
However, the SARS-CoV-2 has spread in our lives and it has no time to go away. Special attention of course, should be paid to the treatment of COVID-19 patients, but prevention by diets and protection should not be forgotten. ACE2 is a good and a logical target, and proper nutrition to maintain the physiological level of ACE2 expression is needed. Proper use of compounds such vitamin C and prevention of vitamin E deficiency that increase ACE2 expression may be important for prevention of COVID-19. In addition, we must keep in mind that the activity of the enzyme depends on sex and age.
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Conflicts of interest
There are no conflicts of interest.
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